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Alternative to the Gold Standard
of Bowel Test
(Colon Cancer Check)

By Dr. Peter W. Kujtan, B.Sc., M.D., Ph.D.

Article printed page A9 in the April 14, 2010 issue of
The Mississauga News under the feature: Health & Beauty, Medicine Matters.
Portrait of Dr. Peter W. Kujtan, supplied 2005
Dr. Peter W. Kujtan

ColonCancerCheck is the program in place to try and screen for signs of colon cancer. I have been fielding a lot of questions about this supposed "new" test. Bowel cancer has had a profound effect on my career and family, and bowel cancer ranks in second place as a cause of cancer deaths. Prevention and early detection are key concepts in dealing with bowel malignancies. There is a lot of publicity surrounding the new endeavors to provide Ontario residents aged 50-74 with bowel screening.

There is nothing new about the test itself. It is an old test in new packaging. This "technology" has been around for decades and is based on a simple chemical principle. Blood contains hemoglobin, which being a protein, can act as an enzyme.

To take advantage of this principle, a sheet of paper is pre-treated by immersion in a solution of guaianoc acid. Stool, which may contain hemoglobin rich blood, is smeared on the paper. A drop of strong base such as hydrogen peroxide is placed on the smear. The peroxidase in the hemoglobin will catalyze oxidation of the guaiaconic acid in the paper to form a blue compound.

Practically speaking, you perform this new self-test by smearing a small amount of stool on the special paper slide. You then label it and seal the special stool-smeared paper into an envelope and mail it to the government assigned laboratory. What could be more fun? It is just like doing your tax return. A lab will process it by adding a drop of hydrogen peroxide and look for the blue color to appear. Your doctor and you will be notified if this happens. In this regard, it really is not a bowel cancer test, but a non-specific test for blood detection.

The current initiative is aimed at identifying more people to add to the screening process. People with early family histories and over the age 50 who have a positive test are sent to obtain a colonoscopy. This is a camera guided tour of your colon. There have been waiting lists to obtain this test, which is the current gold standard. Expansion of current facilities has greatly helped, but providing everyone over 50 with a colonoscopy would be impossible.

A positive test does not mean that you have bowel cancer. It simply suggests that there may be some microscopic blood in your stool. But it could also mean that you ingested other compounds such as red meat, beets or vitamin C. Your bowels are a living organ. Aggravating them by using anti-inflammatories such as aspirin can cause trace amounts of non-cancer bleeding. Similarly, diseases such as colitis can do the same. Bleeding from other causes such as hemorrhoids, urine infections and menstruation can also turn the test positive. But sometimes, small precancerous bowel polyps can bleed as do growing cancer lesions.

One paradox of this system is that a negative test actually hinders your chance for colonoscopy. Some of my patients are savvy enough to do their own research. There are stool tests in existence that use the latest DNA technology to look for genetic mutations in cells that are regularly sloughed off the intestinal walls. Colorectal cancers tend to involve mutations of genes, APC, K-ras and p53 being common ones. It is possible to detect early stages of bowel cancer using this alternate technology, but the testing is more expensive and not a routine part of our health system.

Ever wondered what medical school is like? This spring, you have a chance to sample it, with a series of lectures at UTM (University of Toronto Mississauga) open to the public. I will be a guest lecturer and hope to provide you with some forensic anecdotes. Visit Mini-Med School at the University of Toronto to register.

Related resources:

Colorectal Cancer Screening from Cancer Care Ontario.

About Colorectal Cancer Screening.

ColonCancerCheck Overview: How the Program Works.

Diagnosis of Cancer.

Cancer Treatment and Cancer Survival.

Colorectal Cancer: "Don't die of embarrassment - get screened."

Colorectal Cancer. Also called: Colon cancer, Rectal cancer. From MedlinePlus. In the United States, colorectal cancer is the fourth most common cancer in men and women. Caught early, it is often curable.

It Never Hurts to Check from Ontario Ministry of Health and Long Term Care. Colon cancer (also referred to as colorectal cancer) is a cancer that can be cured 90 per cent of the time if detected early through regular screening.

Frequently Asked Questions About Colorectal Cancer from Ontario Ministry of Health and Long Term Care. Colorectal cancer is the second deadliest cancer in Canada.

Ontario introduces $193M colon cancer screening program from CBC News, January 23, 2007.

What does the ColonCancerCheck program do? The ColonCancerCheck program screens all average risk Ontarians aged 50 years and older for colorectal cancer using the Fecal Occult Blood Test (FOBT) . An FOBT detects trace amounts of blood in the stool. Ontarians at increased risk are screened for colorectal cancer by colonoscopy.

This Smudge Is for Health (Fecal Occult Blood Test - FOBT). By Dr. Peter W. Kujtan, B.Sc., M.D., Ph.D.

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